Vincent DiFate has had his paintings exhibited in numerous group and one-man shows at museums and galleries throughout North America, Europe, Asia and Japan. A partial list of venues are: the Hayden Planetarium in New York City, the National Air and Space Museum, the U.S. Air Force Art Collection in Washington, D. C., the Society of Illustrators in New York City, the National Aeronautics and Space Administration at Cape Canaveral, Florida, the New Britain Museum of American Art in Connecticut, and in the University of Kansas Center for Science Fiction Studies at Lawrence, Kansas. He was commissioned by NASA in 1985 to create the official painting of the International Space Station currently being assembled in Earth orbit. That painting is on display at the Kennedy Space Center at Cape Canaveral.

DiFate has received many awards for his paintings and has published two major books; DiFate's Catalog of Science Fiction Hardware (Workman Publishing Co, 1980) and Infinite Worlds: The Fantastic Visions of Science Fiction Art (Penguin Studio Books, 1997). The award winning Infinite Worlds is the first comprehensive history of science fiction art in America.

DiFate is an Assistant Professor at the Fashion Institute of Technology in New York City, where he teaches courses on the History of Illustration and Color Theory. He served two terms as president of the Society of Illustrators (1995-1997), an organization of which he is a Life Member, chaired the Permanent Collection Committee for the Museum of America Illustration (SI) from 1985 to 1995, and has served on the Illustration Committee for the Sanford Low Collection of the New Britain Museum of American Art since 1993. He is also a founding member and a past president of the Association of Science Fiction/Fantasy Artists.